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SCIENCE

Immunostimulatory Activity

  • Lactobacillus sakei K040706 activates NO, TNF-α production expressed in activated immune cells.
  • Lactobacillus sakei K040706 promotes immune response by activating IKK-α phosphorylation.
  • The immune-enhancing response is induced by stimulation of TLR2 by K040706.

NO producing

TNF-α

IKK-α phosphorylation

TLR2 receptor activation

Macrophage Activation Mechanism

Enhancement of immunity

  • Spleen index of negative control (Immunosuppression alone-treated) were significantly reduced as compared with controls.
  • Spleen index of K040706_L and K040706_H were increased versus negative control.

Maintenance of intestinal microbial balance

  • Lactobacillus ratio of negative control(Immunosuppression alonetreated) were significantly reduced as compared with control.
  • Lactobacillus ratio of K040706_L and K040706_H were significantly increased versus negative control.

Prevention of gastrointestinal infection

  • Negative control (DSS treatment induced acute colitis) were increased DAI values as compared with control.
  • Treatment of K040706_H significantly reduced DAI values versus negative control.
  • Positive control (5-ASA treatment) had similar suppressive effects.
  • DSS-induced colon tissue injury was associated with a partial destruction of the epithelial architecture.
  • The evaluation of colons from the K040706-treated group with DSS revealed a significant reduction in crypts epithelium distortion and inflammatory cellular infiltration compared to DSS group.

Prevention of gastrointestinal infection

  • Negative control (Influenza virus injection) were 10% survival rate after 14 days.
  • Treatment of K040706_H were 50% survival rate after 14 days.

References

Journal of Functional Foods, 2017, 29 : 256-268 l International Immunopharmacology, 2015, 28 : 88-96